Date: Tuesday, 10 March 2026

Time: 07:00 [PST] 10:00 [EST] 15:00 [GMT]

Duration: 1 hour

This presentation presents a streamlined and sensitive LC–MS workflow for four key quantitative pharmacokinetic/pharmacodynamic (PK/PD) assays using trastuzumab deruxtecan (TDx) in rat plasma on a triple quad mass spectrometer. Each of these assays provides unique insights into the behavior of the antibody drug conjugate (ADC), enabling a comprehensive PK/PD evaluation. Sensitivity and quantitative performance are critical for ADC analysis, enabling accurate and thorough assessments of drug stability, safety and therapeutic efficacy. The session will highlight assay sensitivity, method robustness and applicability to bioanalysis.
 
This session provides valuable insights into:
  • Optimal workflows for ADC quantitation.
  • Low levels of LLOQs for payload and peptide assays on the SCIEX 7500+ system.
  • Sensitivity and reproducibility in ADC quantitative assays.

 Meet the speaker:

Ebru Selin SelenEbru Selin Selen
Senior Scientist
SCIEX

 

Ebru earned her PhD at the University of Wisconsin–Madison (WI, USA) and completed postdoctoral training at Johns Hopkins School of Medicine (MD, USA), developing mass spectrometry (MS) and NMR methods to study liver metabolism. At SCIEX, she partners with pharma leaders to apply next-generation MS technologies and create innovative workflows that drive sensitivity, selectivity and robustness in drug development.

 

 
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